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1. Demonstrate knowledge and understanding of basic ideas and concepts in chemistry and molecular genetics.
NOTE UPDATED exam paper to the LIVE EXPERT Case Study (if any)
Unit title & code
BHS006-1: Chemistry and Molecular Genetics
Assignment number and title
001 / 004 Genetics Report (REFERRAL)
Assignment type
BREO (electronic)
Weighting of assignment
25%
Size or length of assessment
1250 words
Unit learning outcomes
1
2
What am I required to do in this assignment? This referral assignment should be completed by: a) any student who has a deferred result for unit BHS006-1 shown on eVision/SITS and obtained less than 40% for assessment 1. b) or, any student who has approved mitigation for the original BHS006-1 assessment 1.
What does this assignment involve? using complete sentences and paragraphs, and with appropriate referencing ). These questions guide you through the expected understanding of the science related to the mitotic chromosomes practical that was carried out in this unit and signify understanding that should have been shown in the original assignment report.
What do I need to do to pass? (Threshold Expectations from UIF) In order to pass Assessment 1 you will need to:
Accurately observe and describe DNA molecules
Analyse and interpret the relationship between DNA structure and function
Present information clearly in an appropriately structured formal report
How do I produce high quality work that merits a good grade? Clarity of English language and presentation is essential throughout. Your ability to follow the instructions within this assignment brief is also essential. These are basic professional skills expected by all employers.below above must before not not not
All text must be written in your own words . Copying text from reference sources, friends or lab partners is PLAGIARISM. Copying text from somewhere else and then changing a few words in it here and there is also PLAGIARISM. You must read and understand your reference source, then explain your understanding in your own unique words, and then provide a citation – e.g. (Patel, 2014)
Your report must answer each of the short answer questions below. The answer to each question should be numbered
The report must be no more than 1250 words . The word count does not include references. Excessive word counts will negatively affect grading. Clarity of English language and presentation is essential throughout.
You must include at least three peer-reviewed scientific journal articles or textbooks as sources. All sources must be listed in correct UoB Harvard format in a single reference list at the end of your report.
Questions to be answered in your report:
Eukaryotic chromosomes are made from a material called chromatin. Explain what chromatin is and describe the chromatin structure of eukaryotic chromosomes.
Describe the changes in chromatin structure that occur during mitosis.
Explain the mechanism of mitotic chromosome separation (anaphase) and include in your answer the following terms: centromere, centrosome, kinetochore, sister chromatids and spindle fibres.
Define interphase and explain what is happening during this part of the cell cycle.
What does the percentage of total cells in each phase of cell cycle (at any one point in time) tell you about the approximate duration of each phase?
Table 1 . Distribution of cell cycle phases for onion roots grown in different conditions.
Growth conditions
Interphase
Prophase
Metaphase
Anaphase
Telophase
Control group (In
320
11
7
8
4
sunlight on Earth)
In dark cellar on Earth
300
5
2
1
1
In sunlight on Earth
408
30
19
15
8
with BabyBio plant feed
In sunlight on space
420
26
16
14
4
station
Given the information in Table 1, calculate the mitotic index values of these four onion root samples. Show your calculation in full. Mitotic Index (%) = No. of mitotic cells counted (P+M+A+T) x 100
Total no. of cells counted (I+P+M+A+T)
Create a table giving the number of interphase cells, the number of M-phase (P+M+A+T) cells, and the mitotic index for each of the four datasets in Table 1.
Plot a column graph comparing mitotic index values of the four datasets in Table 1.
Compare the Dark cellar dataset, the BabyBio dataset, and the Space dataset (one at a time) against the Control sunlight dataset using Fisher’s exact test and create a table of the resulting p-values (or add sensibly to Table 1). (To run the Fisher’s exact test go to http://www.socscistatistics.com/tests/fisher/Default2.aspx, enter the Control group data and one other dataset in the 2x2 table, select a significance level of 0.05, and calculate the resulting p-value. Then repeat with the other two datasets in turn against the control group). Compare interphase cells vs. all cells in M-phase (P+M+A+T) added up, e.g. as follows:
Cells in
Total cells in M-
interphase
phase
Control
320
30 (11+7+8+4)
Dark cellar
300
9 (5+2+1+1)
What does a p-value actually tell you about any datasets that are being compared? (i.e. what is the purpose of the statistical testing? Do not
With reference to the relevant mitotic index values and p-value, explain what effect growing onion roots in a dark cellar has had.
With reference to the relevant mitotic index values and p-value, explain what effect growing onion roots in sunlight with BabyBio plant feed has had.
With reference to the relevant mitotic index values and p-value, explain what effect growing onion roots in space has had.
References at least three peer-reviewed scientific journal articles or textbooks as sources. These should be listed in correct UoB Harvard format in a single reference list.
How does this assignment relate to what we are doing in scheduled sessions?
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