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£79 Acid-peptic disease includes peptic ulcer (gastric and duodenal), gastroesophageal reflux and Zollinger – Ellison syndrome.
After completing this chapter the student will be able to:
Describe different drugs used for treatment of gastrointestinal diseases,
Understand the basic pharmacological principles of these drugs
Know the adverse effects of these drugs,
Use the drugs rationally.
The pharmacologically treatable disorders of impairements of normal motility, digestion, absorption, secretions of the gastrointestinal tract include peptic ulcer, reflux esophagitis, Zollinger-Ellison syndrome, gastroparesis, constipation, diarrhea, inflammatory diseases and infections. This chapter discusses different drugs used for treatment of these disorders. However, anti-infective drugs will be discussed in other chapter.
Drugs used in Acid-peptic disease:
Acid-peptic disease includes peptic ulcer (gastric and duodenal), gastroesophageal reflux and Zollinger – Ellison syndrome.
Peptic – ulcer disease is thought to result from an imbalance between cell – destructive effects of hydrochloric acid and pepsin and cell-protective effects of mucus and bicarbonate on the other side. Pepsin is a proteolyic enzyme activated in gastric acid, also can digest the stomach wall.
A bacterium, Helicobacter pylori is now accepted to be involved in the pathogenesis of ulcer.
In gastroesophageal reflux, acidic stomach contents enter into the esophagus causing a burning sensation in the region of the heart; hence the common name heartburn, or other names such as indigestion, dyspepsia, pyrosis, etc.
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